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The Genome Variation Server (GVS) is a local database hosted by the SeattleSNPs Program for Genomic Applications (PGA).
The objective of this database is to provide a simple tool for rapid access to human genotype data found
in dbSNP, and to provide tools for
analysis of genotype data. The current release of genotype data found in the GVS database is that of dbSNP build 128 (October 2007).
The variation locations are mapped to the human genome reference sequence of March 2006 (UCSC hg18, NCBI build 36).
This GVS database contains 4.5 million variations with corresponding genotype data.
To be included in our database, a variation must have genotype data, and it must be uniquely mapped to the human genome by dbSNP.
As most submitters to dbSNP report double genotypes for X and Y chromosome variations, we put double genotypes in our
database, and changed single genotypes to (homozygous) double genotypes. If a genotype on the Y chromosome was reported to be heterozygous, we
omitted it. We have not corrected the frequencies for male X chromosome genotypes.
A list of the files from which the database has been built can be found here.
The GVS will continue to be updated with new analysis features and with more genotype data as it becomes available.
This site is supported by PGA grants HL66682 and HL66642 from the National Heart, Lung, and Blood Institute (NHLBI).
Please see the terms of service.
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National Heart, Lung, and Blood Institute
Programs for Genomic Applications